Fire crews were called to the 200 block of Avenue S South at 3:28 a.m. and found flames rising from the back of the house.
One person was able to evacuate the building safely, but two dogs were later found dead inside.
The fire was brought under control at 3:58 a.m.
Investigators said the fire originated from the rear deck of the home, but a cause has not yet been determined.
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